Autoimmune Reactivity Screen (Array 5)

Cyrex Array 5 – Predictive Antibody Screening

Assesses multiple tissues commonly target by auto-antiobodies, including thyroid, joints, heart, gut, brain, pancreas, liver, ovaries, bone and others. Autoimmune disorders occur when your immune system “attacks itself”. Your body’s affected organ or tissue (eg thyroid, colon, pancreas, joints, etc) is “mistaken” for a foreign/toxic antigen (eg bacteria, toxic chemical or food antigen such as gluten). In a similar way to which you may have an allergic (immune) reaction to gluten or pollen or parabens, your body reacts and begins to mount an immune response to the particular organ or tissue that it mistakes for a foreign antigen, thus it “attacks self”. As time progresses, if the underlying causes are not addressed, the tissue/organ may become sufficiently damaged/destroyed so as to require medical attention (eg thyroid hormone for autoimmune thyroiditis, or insulin for type-1 diabetes). Your condition may then be medically defined as “autoimmune disease”.

Auto-immune disorders commonly occur in clusters, so that if you have an autoimmune disorder, you are at a higher risk of developing more. In other words, they exhibit a tendency to “multiply”.

Leaky gut and food sensitivities are commonly linked with auto-immunity, as foreign particles, microbes, chemicals and undigested food are able to gain entry to your bloodstream and thus circulate throughout your body. The manner in which your immune system may intervene, and the tissues/organs that may be targeted, and to what degree, depend son your unique biochemical individuality as well as multiple environmental factors. Susceptibility to various different autoimmune disorders can vary vastly between identical twins.

Many autoimmune conditions are reversible, if detected early enough (especially if identified before the “end-stage” at which medical diagnosis occurs). Once reversal has been initiated, you may be able to avoid developing other autoimmune diseases, if you address the underlying causes, triggers and mediators of your health issues. Even if your condition is not fully reversible, it might be possible to reduce medication (strictly under medical supervision) applying a functional medicine approach.

The sooner an autoimmune condition is identified, the greater chance of reversal or at least minimizing tissue damage. This is why we use Cyrex Array 5: Multiple Autoimmune Reactivity Screen™.

Cyrex Array 5 detects the presence of “auto-antibodies” in your body, by measuring both IgG and IgA antibodies to 27 different human tissues. Auto-Antibody identification is the first stage in detecting auto-immune disease and the tissues/organs that are affected. Antibodies can be present in your body many years prior to a medical diagnosis and before you exhibit signs and symptoms of disease.

Array 5 is an economical and effect way to assess possible tissue damage to multiple organs of your body, and helps us assess predictive antibodies. Elevated numbers of “predictive antibodies” are measurable as much as ten years before the clinical onset of the disease. Early detection and identification of pathogenesis, before extensive tissue damage has occurred, provides opportunity to address and arrest your autoimmune disorder, and in some cases entirely reverse the condition.

Under certain circumstances you may be at increased risk of developing autoimmune disorders. This test may be useful for you if you suffer from, have been diagnosed with, or suspect you have any of the following health conditions:

  • Gluten sensitivity / coeliac disease
    • Gluten produces digestive symptoms in only a minority of individuals. In the majority of people, gluten can damage non-intestinal tissue or organs such as brain, thyroid heart, skin, joints or respiratory tract.
  • Chronic intestinal permeability (“leaky gut”)
    • Leaky gut is known as the gateway for environmentally-induced autoimmune disorders.
  • Diagnosis of any autoimmune disease
    • Such individuals commonly develop further autoimmune conditions. Using the results from Array 5 can help us effectively target your health needs; in this way you may be able to avoid developing other autoimmune disorders, and potentially reduce your medication (under strict medical supervision).
  • Chronic toxin/chemical exposure
    • All of us are exposed to toxic chemicals. Even unborn fetuses when tested are found to contain multiple chemicals.
    • Some people react to the chemicals that we are exposed to, and sometimes these chemicals trigger auto-immune reactivity, and/or adversely influence our health in other ways. This may be because you have had increased exposure to chemicals, or because you are harbouring chronic infections, or have reduced detoxification capacity.
    • If you suspect you are reacting to chemicals, you may also wish to consider Cyrex Array 11: Chemical Immune Reactivity Screen, to assess the degree at which many chemicals might be triggering auto-immune reactivity and therefore proving detrimental to your health.
  • Infectious Agents including chronic infections, viruses and moulds
    • Latent infections as triggers of autoimmunity may be identified in Cyrex Array 12: Pathogen Associated Immune Reactivity Screen. If you suspect you have a latent infection as well as possible auto-immune disorders, then you are advised to run Array 12.
    • If Array 12 has already identified infectious agents in you, then it is possible that your immune system is mistaking parts of your body for foreign antigens, via a process known as “molecular mimicry”.
    • In this case you are advised to use Cyrex Array 5 and possibly Array 20: Blood Brain Barrier Permeability Screen, to figure out which tissues/organs are under attack, so that you can do something about it before such time as the damage becomes irreversible.
  • Any idiopathic condition (i.e. spontaneous symptom onset, often without apparent cause)

This is not a test to diagnose disease, but rather identify the presence of auto-antibodies to tissues within your body. Thus providing a window of opportunity to address, prevent deterioration of, and possibly reverse your condition.

Predictive Antibody tests 27 Different Tissues and Organs:

1. Parietal Cell + ATPase IgG + IgA Combined
2. Intrinsic Factor IgG + IgA Combined
3. ASCA + ANCA IgG + IgA Combined
4. Tropomyosin IgG + IgA Combined
5. Thyroglobulin IgG + IgA Combined
6. Thyroid Peroxidase (TPO) IgG + IgA Combined
7. 21 Hydroxylase (Adrenal Cortex) IgG + IgA Combined
8. Myocardial Peptide IgG + IgA Combined
9. Alpha-Myosin IgG + IgA Combined
10. Phospholipid IgG + IgA Combined
11. Platelet Glycoprotein IgG + IgA Combined
12. Ovary/Testis* IgG + IgA Combined
13. Fibulin IgG + IgA Combined
14. Collagen Complex IgG + IgA Combined
15. Arthritic Peptide IgG + IgA Combined
16. Osteocyte IgG + IgA Combined
17. Cytochrome P450 (Hepatocyte)
18. IgG + IgA Combined
19. Insulin + Islet Cell Antigen
20. IgG + IgA Combined
21. Glutamic Acid Decarboxylase 65 (GAD 65)
22. IgG + IgA Combined
23. Myelin Basic Protein IgG + IgA Combined
24. Asialoganglioside IgG + IgA Combined
25. Alpha + Beta Tubulin IgG + IgA Combined
26. Cerebellar IgG + IgA Combined
27. Synapsin IgG + IgA Combined

Special Note

  • Immunosuppressant and corticosteroid drugs can reduce antibody production and distort test results eg with false negatives when results would otherwise be positive.
  • Please contact us for more information if you are unsure when/whether to proceed with this test.
  • Many studies shows that autoimmune antibody can be elevated in the blood many years before symptoms occur. If detected early, natural and/or medical interventions can begin in order to minimize long-term illness and promote a better quality of life.
  • Multiple autoimmune antibodies against your bodies organs are tested in this panel due to the fact that more than 40% of those with auto-antibodies to one organ have auto-antibodies to other organs and tissues of the body.

Learn More About The Tissues Being Tested

Array 5 – Systemic Autoimmune Reactivity Screen™

ANTIGEN ANTIBODIES ASSOCIATED WITH*
*This test by itself is not diagnostic for any condition or disease
BODY TISSUE
Parietal Cell + ATPase IgG + IgA Combined Gastric Autoimmunity
Chronic Atrophic Gastritis
Pernicious Anemia
Gastrointestinal
Intrinsic Factor
IgG + IgA Combined
ASCA + ANCA
IgG + IgA Combined
Autoimmune Gastritis Pernicious Anemia
Behçet’s Syndrome with GI Involvement
Crohn’s Disease
Long-term use of Anti-Thyroid Medication
Ulcerative Colitis
Vasculitis
–
Tropomyosin
IgG + IgA Combined
Autoimmune Cardiovascular Diseases
Colon Autoimmunity Ulcerative Colitis
–
Thyroglobulin
IgG + IgA Combined
Autoimmune Thyroid Disease
Hashimoto’s Thyroiditis
Graves’ Disease
Thyroid
Thyroid Peroxidase(TPO)
IgG + IgA Combined
Autoimmune Thyroid Disease
Graves’ Disease
Hashimoto’s Thyroiditis
Vitiligo
–
21 Hydroxylase
(Adrenal Cortex)
IgG + IgA Combined
Addison’s Disease
Adrenal Autoimmunity
Adrenal Insufficiency
Atrophic Gastritis
Autoimmune Endocrine Disorders
Diabetes Insipidus
Graves’ Disease
Hashimoto’s Thyroiditis
Vitiligo
Adrenal
Myocardial Peptide
IgG + IgA Combined
Acute Rheumatic Fever
Autoimmune Myocarditis
Heart Disease
Heart Trauma
Rheumatic Heart Disease
Cardiovascular
Alpha-Myosin
IgG + IgA Combined
Autoimmune Myocarditis
Dilated Cardiomyopathy
Myasthenia Gravis
Rheumatic Heart Disease
–
Phospholipid
IgG + IgA Combined
Antiphospholipid Syndrome
Non-Insulin-Dependent Diabetes Mellitus (NIDDM)
Systemic Lupus Erythematosus (SLE)
Cardiovascular and Endocrine
Platelet Glycoprotein
IgG + IgA Combined
Arterial Thrombosis
Autoimmune Thrombocytopenia
Cardiovascular Disease
Coronary Artery Disease
Systemic Lupus Erythematosus (SLE)
–
Ovary/Testis
IgG + IgA Combined*
Ovary and Testis are tested together to avoid any confusion
arising out of potential cross-reactivity.
Autoimmune Endocrine Disorders
Autoimmune Polyendocrine Syndrome Type 1
Hypogonadism
Premature Menopause
Premature Ovarian Failure
Reproductive
Fibulin
IgG + IgA Combined
Atherosclerotic Lesions
Osteoarthritis
Joint
Collagen Complex
IgG + IgA Combined
Arthritis
Goodpasture’s Syndrome*
Type 1 Bullous SLE *rat study
–
Arthritic Peptide
IgG + IgA Combined
Mixed Connective Tissue Disease
Osteoarthritis Rheumatoid Arthritis
–
Osteocyte
IgG + IgA Combined
Osteoclastogeneis
Osteopenia
Osteoporosis
Bone
Cytochrome P450 (Hepatocyte)
IgG + IgA Combined
Autoimmune Hepatitis Type 2
Chronic Hepatitis C
Heptocellular Carcinoma
Liver/Mycrosomal Autoimmunities
Liver and Endocrine
Insulin + Islet Cell Antigen
IgG + IgA Combined
Insulin Autoimmune Hypoglycaemia
Insulinoma
Type 1 Diabetes
Unexplained Hypoglycaemia
–
Glutamic Acid Decarboxylase 65
(GAD 65)
IgG + IgA Combined
Battan Disease
Celiac Disease
Cerebellar Ataxia
Non-Celiac Gluten Sensitivity
Polyendocrine Autoimmune Syndrome
Stiff-Person Syndrome
Type 1 Diabetes
–
Myelin Basic Protein
IgG + IgA Combined
Multiple Sclerosis
Autism
PANDAS / ANDAS / OCD
Systemic Lupus Erythematosus (SLE)
Toxin Exposure
Neuronal
Asialoganglioside
IgG + IgA Combined
Chronic Inflammatory Demyelinating Polyneuropathy
Cerebrovascular Accidents
Cranial Trauma
Guillain Barré Syndrome
Miller Fisher Syndrome
Motor Neuron Disease
Multifocal Motor Neuropathy
Multiple Sclerosis
Myasthenia Gravis
PANDAS / ANDAS / OCD
Rheumatoid Arthritis
Sensorimotor Neuropathy
Systemic Lupus Erythematosus (SLE)
–
Alpha + Beta Tubulin
IgG + IgA Combined
Alcoholic Liver Disease
Demyelinating Disease
Graves’ Disease
Hashimoto’s Thyroiditis
Infectious agent exposure
PANDAS / ANDAS / OCD
Rheumatoid Arthritis
Recent Onset Type 1 Diabetes Toxin Exposure
–
Cerebellar
IgG + IgA Combined
Autism
Celiac Disease
Gluten Ataxia
Paraneoplastic Cerebellar Degeneration Syndrome
Opsoclonus-Myoclonus Syndrome
–
Synapsin
IgG + IgA Combined
Demyelinating Diseases
Inhibited Neurotransmitter Release
Systemic Lupus Erythematosus (SLE)
Multiple Sclerosis
–